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Moumoujus

ALSTONIA SCHOLARIS BARK EXTRACT.

Valuable CAS 91745-20-9 / BUFFERING, SKIN PROTECTING

Alstonia Scholaris Bark Extract is a multi-functional botanical ingredient recognized for its potent anti-inflammatory and antioxidant properties. It notably reduces skin irritation, particularly when combined with retinoids, while also supporting anti-aging pathways.

Summary

Antioxidant Anti-inflammatory Anti-acne Soothing Skin protecting Humectant pH-buffering Anti-aging

Science

Mechanism of Action

This extract exerts its anti-inflammatory effects by significantly inhibiting inflammation induced by all-trans retinoic acid and suppressing pro-inflammatory cytokines such as monocyte chemoattractant protein-1 (MCP-1) by 82.1% and interleukin-8 (IL-8) by 26.3% in vitro. It also demonstrates strong antioxidant capabilities through DPPH free radical scavenging, superoxide anion scavenging, and ferrous ion chelating. Furthermore, it enhances the anti-aging benefits of retinoids by strengthening their ability to inhibit matrix metalloproteinase-1 (MMP-1) expression, and possesses antimicrobial properties.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

0.01%

Key findings

  1. 01 Significantly inhibited all-trans retinoic acid-induced inflammation in human HaCat keratinocyte cells, suppressing MCP-1 by 82.1% and IL-8 by 26.3% in vitro. It also decreased retinol-induced skin irritation in a cumulative irritation patch test and strengthened retinoids' ability to inhibit MMP-1 expression.
  2. 02 Displayed strong antioxidant activity (90%) through DPPH free radical scavenging.
  3. 03 Demonstrated ferric reducing power of 130.70 µmoles/mg in a FRAP assay. IC50 values were 1.21 mg/mL in a DPPH assay and 210 µg/mL in an ABTS assay.

Transparency

Dusting Analysis

Not commonly dusted

There is no evidence suggesting this ingredient is commonly used at sub-efficacious concentrations for marketing purposes.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

The extract functions as a buffering agent, which can help in stabilizing product pH.

Synergies

  • Retinoids (to mitigate irritation and enhance anti-aging effects)

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

No specific safety review by CIR, SCCS, or FDA for topical cosmetic use is available. While oral toxicity studies in animals indicate adverse effects at high doses (500 and 1000 mg/kg) with prolonged use, this data is not directly transferable to topical skincare. Dermal toxicity reports suggest none found, and its ability to reduce irritation in human patch tests further supports a low risk profile.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Alstonia Scholaris Bark Extract is a valuable ingredient for its ability to reduce inflammation, provide antioxidant protection, and enhance the benefits of retinoids while mitigating their common side effects.

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