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Moumoujus

ALPHITONIA EXCELSA LEAF EXTRACT.

Valuable / SURFACTANT - CLEANSING

Derived from the leaves of the Australian Red Ash tree, Alphitonia Excelsa Leaf Extract is recognized for its broad-spectrum antimicrobial and anti-inflammatory properties. Rich in triterpenoid saponins, it offers a multi-functional approach to skin health, particularly for conditions associated with microbial imbalance and inflammation.

Summary

Antimicrobial Anti-inflammatory Cleansing

Science

Mechanism of Action

The efficacy of Alphitonia Excelsa Leaf Extract stems from its triterpenoid saponin content, which is primarily responsible for its observed anti-inflammatory action. Furthermore, this extract exhibits significant antimicrobial and antibacterial activity against a diverse array of both Gram-positive and Gram-negative pathogenic bacteria, positioning it as a potent antiseptic agent for topical applications.

Research

Clinical Evidence

Medium confidence
Effective range 0.0118–0.1%
Optimal

N/A

Key findings

  1. 01 An *in vitro* study demonstrated that a methanolic extract of Alphitonia excelsa leaves exhibited antimicrobial activity across various pathogenic bacteria. Minimum Inhibitory Concentrations (MICs) ranged from 118 µg/mL (0.0118%) for *P. mirabilis* to 927 µg/mL (0.0927%) for *S. aureus*. Other notable inhibitions included *A. hydrophilia* (MIC 225 µg/mL or 0.0225%), *E. coli* (MIC 415 µg/mL or 0.0415%), and *B. cereus* (MIC 563 µg/mL or 0.0563%).
  2. 02 At a concentration of 1000 µg/mL (0.1%), the methanolic extract showed significant growth inhibition in cultures of *P. mirabilis* and *B. cereus* within a rapid 1-hour exposure period.

Transparency

Dusting Analysis

Commonly dusted
Min. effective
0.01%
Red flag below
0.005%

The observed antimicrobial activity occurs at relatively low concentrations, with MICs ranging from 0.0118% to 0.0927%. Formulations containing this extract significantly below these thresholds may not deliver the demonstrated antimicrobial benefits, indicating potential dusting.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

An *Artemia franciscana* nauplii bioassay indicated nontoxicity with LC50 values substantially exceeding 1000 µg/mL, suggesting potential safety for topical application. However, comprehensive safety assessments by regulatory bodies such as CIR, SCCS, or FDA are not available. Further studies using human cell lines are recommended to thoroughly evaluate its safety profile.

Your Skin

Skin Compatibility

Yes Normal
No Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Alphitonia Excelsa Leaf Extract offers promising antimicrobial and anti-inflammatory properties, making it a valuable ingredient for managing blemish-prone or compromised skin, though further human clinical data is recommended for a complete understanding of its efficacy and safety profile.

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