ALPHA-SANTALYL BUTYRATE.

The proposed skincare mechanisms are primarily linked to its parent compound, butyrate. Butyrate influences cutaneous microbial profiles, fortifies skin immune defenses, and provides protection against infection and UV radiation. It acts as an anti-inflammatory agent by inhibiting cytokines and inflammatory cells, and through histone deacetylase (HDAC) inhibition, it promotes the proliferation of regulatory T cells (Tregs) crucial for wound healing, hair follicle regulation, and stem cell differentiation. Furthermore, it enhances skin barrier function by modulating mitochondrial metabolism and function, boosting the synthesis of long-chain and very long-chain fatty acids vital for ceramide generation, and promoting keratinocyte differentiation via HDAC inhibition. Specifically, butyrate has been shown to suppress IL-33 expression and mitigate skin inflammation through HDAC3 inhibition.