Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

ALPHA-SANTALOL.

Questionable CAS 115-71-9 / PERFUMING

Derived from sandalwood, Alpha-Santalol is a fragrant compound recognized for its multifaceted biological activities. It exhibits antioxidant, antimicrobial, and anti-inflammatory properties, alongside promising chemopreventive effects, making it a subject of interest in precision skincare formulations.

Summary

fragrance anti-inflammatory antimicrobial antioxidant chemopreventive collagenase inhibitor

Science

Mechanism of Action

Alpha-santalol operates through several pathways: it acts as an anti-inflammatory agent, inhibits lipid peroxidation, and provides antimicrobial benefits. Its notable chemopreventive capacity against UVB-induced skin tumors is linked to the activation of proapoptotic caspases, induction of G2/M cell cycle arrest, and suppression of epidermal ornithine decarboxylase (ODC) activity. Furthermore, it can induce apoptotic death in human epidermoid carcinoma cells and may suppress collagenase (MMP-1) activity, contributing to its potential in skin health.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

5%

Key findings

  1. 01 Topical application at 5% significantly reduced UVB-induced skin tumor development in murine models.
  2. 02 In vitro studies showed Alpha-Santalol induced G2/M phase cell cycle arrest in human epidermoid carcinoma and melanoma cells.

Transparency

Dusting Analysis

Not commonly dusted

Alpha-Santalol possesses well-documented active properties including anti-inflammatory, antioxidant, and chemopreventive effects, suggesting its inclusion is typically for functional benefit rather than solely for marketing claims. While it functions as a fragrance, its therapeutic potential is scientifically supported.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Santalol, containing Alpha-Santalol, generally maintains stability and does not cause discoloration in most formulation media.

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
0.15%
Sensitization risk High

The EU Scientific Committee on Consumer Safety (SCCS) classifies Alpha-Santalol as an 'established contact allergen in humans' based on various positive test reactions. While one human maximization test showed no sensitization at 20%, diagnostic patch tests have reported positive reactions at concentrations up to 10%. A cosmetic use level of 0.15% has been noted as a practical limit in formulations. Caution is strongly advised, especially for individuals with sensitive skin or known allergies, despite INCIDecoder rating its irritancy as low.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

Despite its promising anti-inflammatory, antioxidant, and chemopreventive properties, Alpha-Santalol is classified as an established human contact allergen, significantly limiting its safe inclusion in precision skincare formulations, especially for sensitive skin.

Related

Similar Ingredients

Finding similar ingredients…