Science
Mechanism of Action
It modulates gene expression, upregulating pathways for metabolism and downregulating pro-inflammatory mRNA. The extract boosts aquaporin-3 (AQP3) for superior hydration and promotes cell repair via epidermal growth factor (EGF) induction.
Research
Clinical Evidence
High confidence2%
Key findings
- 01 At 2%, increased AQP3 expression by 120%, accelerated wound healing fourfold, and reduced inflammatory markers COX-2 by 43% and iNOS by 48% in HaCaT cells. Clinically, it reduced skin temperature by 7.4°C after heat irritation.
- 02 Dose-dependently (0.5-2%) reduced inflammatory mediators under UV exposure in HaCaT cells, confirming protective mechanisms against photodamage without cytotoxicity.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
This extract is highly stable at 25-27°C, but degradation, observed as discoloration, occurs above 40°C or at alkaline pH (>7.0). Bioreactor cell culture ensures consistent quality and purity.
Conflicts
- Alkaline ingredients
- Strong oxidizers
- High heat (>40°C) during processing
Safety
Safety Profile
While generic Aloe Barbadensis extracts are CIR safe, this specific phytoplacenta cell culture extract has not yet undergone separate CIR or SCCS review. Clinical human tests at 2% concentration showed no irritation.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This potent phytoplacenta extract delivers significant hydration, accelerated healing, and powerful anti-inflammatory benefits, making it a valuable addition for all skin types.
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References
Sources