Science
Mechanism of Action
This extract boosts skin hydration by upregulating Aquaporin-3 (AQP3) expression in keratinocytes and exerts anti-inflammatory effects by inhibiting pro-inflammatory mediators COX-2 and iNOS. Bioactive compounds like acemannan also promote fibroblast proliferation and collagen synthesis.
Research
Clinical Evidence
High confidence2%
Key findings
- 01 In vitro studies at 2.0% demonstrated a 120% increase in AQP3 protein expression, a fourfold increase in wound healing area, and significant reductions of 43% in COX-2 and 48% in iNOS. Dose-dependent enhancement of wound healing and anti-inflammatory activity was observed from 0.5% to 2.0% in human keratinocytes and UV-exposed skin models.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Highly stable in aqueous systems, typically prepared as a hydroglycolic or water-based extract. It is sensitive to high temperatures, which can degrade its beneficial polysaccharides.
Conflicts
- strong oxidizing agents
- high concentrations of alcohol (may cause polysaccharide precipitation)
Safety
Safety Profile
The CIR Expert Panel considers Aloe Barbadensis-derived ingredients safe, provided phototoxic anthraquinone levels do not exceed 50 ppm. Callus extract is generally produced under controlled conditions that minimize these impurities.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This extract is a valuable multi-functional ingredient for promoting significant hydration, soothing irritation, and supporting skin regeneration across all skin types.
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