Science
Mechanism of Action
Its efficacy stems from diarylheptanoids and polyphenols, which inhibit key inflammatory pathways (NF-κB, iNOS, COX-2) and reduce pro-inflammatory cytokines. It also acts as a potent antioxidant, scavenging ROS and boosting cellular antioxidant enzymes.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 Topical application at 0.1% to 1.0% significantly reduced inflammation markers and AD-like lesions in vivo.
- 02 In vitro, 50 µg/mL protected human keratinocytes from oxidative stress by reducing ROS and nitric oxide.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The extract is inherently acidic (pH ~4.5-4.7) and contains polyphenols susceptible to oxidative degradation, which may slightly acidify formulations over time. Stability can be enhanced by incorporating antioxidants like Vitamin E or chelating agents.
Conflicts
- Strong oxidizing agents
- Highly alkaline environments
Safety
Safety Profile
Though not CIR-reviewed, related Alnus species have traditional use. Preliminary in vitro studies showed no cytotoxicity at concentrations up to 50 µg/mL.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A valuable ingredient highly effective in reducing inflammation and oxidative stress, suitable for a wide range of skin types, particularly sensitive and atopic-prone.
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References
Sources