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ALMONDAMIDOPROPALKONIUM CHLORIDE.

Valuable CAS 124046-03-3 / ANTISTATIC, HAIR CONDITIONING

A cationic quaternary ammonium compound, Almondamidopropalkonium Chloride primarily functions as a conditioning and antistatic agent in personal care formulations. It helps to smooth surfaces and improve manageability for both hair and skin.

Summary

antistatic hair conditioning surfactant

Science

Mechanism of Action

This positively charged molecule adsorbs onto negatively charged keratin surfaces of hair and skin. This interaction neutralizes static electricity, enhances 'slip,' and visibly smooths the cuticle or stratum corneum for a refined feel.

Research

Clinical Evidence

High confidence
Effective range 0.5–5%
Optimal

N/A

Key findings

  1. 01 Demonstrated non-sensitizing and non-irritating properties in Repeated Insult Patch Tests (RIPT) at usage levels of 0.5-5%.
  2. 02 Found to be non-comedogenic when tested undiluted (100%) in a Rabbit Ear Assay.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 3 – 9
0 7 14

Stability

Highly stable across a broad pH range in both aqueous and alcoholic solutions. Its cationic nature enables clear solutions and provides foaming properties.

Conflicts

  • anionic surfactants
  • anionic rheology modifiers (e.g., Carbomer)
  • strong oxidizing agents

Safety

Safety Profile

CIR Status
Safe as used
Max tested
5%
Sensitization risk Low

The CIR considers this ingredient safe for use up to 5% in formulations, including leave-on products (though typically used below 1% in leave-ons to avoid irritation).

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Almondamidopropalkonium Chloride is a valuable conditioning agent, highly compatible with all skin types due to its low irritancy and non-comedogenic profile, effective at concentrations up to 5%.

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References

Sources