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ALLYLANISOLE.

Questionable CAS 140-67-0 / PERFUMING

Allylanisole, also known as Estragole, is a naturally derived phenylpropanoid found in botanical oils like basil and tarragon. It functions primarily as a fragrance and masking agent in skincare formulations.

fragrance masking antibacterial antifungal

Science

This ingredient offers antibacterial and antifungal properties by disrupting microbial cell membranes. Research also suggests its potential to mitigate oxidative stress by modulating signaling pathways and preserving antioxidant levels in skin aging models.


Research

Medium confidence
Effective range 0.1–1.5%
Optimal

0.00063%

Key findings

  1. 01 Clinical safety evaluations indicate Allylanisole is generally non-sensitizing between 0.1% and 1.5%, though classified as a weak sensitizer in high-dose patch testing. However, IFRA establishes a maximum safe concentration of 0.00063% for facial products to prevent potential genotoxicity and skin sensitization risks.

Transparency

Not commonly dusted

The Formula

Solubility
Oil
Optimal pH 4 – 7.5
0 7 14

Stability

Stable under standard storage conditions but is highly volatile, requiring airtight, light-protected containers. It can isomerize to anethole when exposed to strong bases.

Conflicts

  • Strong oxidizing agents
  • Strong bases
  • Highly acidic environments

Safety

CIR Status
Not reviewed
Max tested
0.00063%
Sensitization risk Low

While CIR has not issued a standalone review, IFRA restricts its use due to potential genotoxicity concerns. Dermal limits are significantly stricter than its GRAS classification for food, especially in leave-on products.


Your Skin

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Questionable

Despite potential antioxidant and antimicrobial properties, Allylanisole's use in precision skincare is highly restricted to extremely low concentrations due to genotoxicity concerns.


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