Science
Mechanism of Action
It functions as an antimicrobial agent and can modulate GABA receptors. However, upon air exposure, it readily autoxidizes into allylic hydroperoxides, acting as haptens that induce allergic contact dermatitis through oxidative stress.
Research
Clinical Evidence
Medium confidence3.7%
Key findings
- 01 At 3.7%, it demonstrates antimicrobial and antifungal efficacy against dermatophytes in shampoo formulations.
- 02 Evaluated at 4.3% as a typical maximum in fine fragrances, noting significant potential for skin sensitization upon autoxidation.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Highly prone to oxidation when exposed to air and light. It is unstable in strongly acidic or alkaline conditions, leading to degradation and loss of aromatic qualities, and is also thermally sensitive.
Conflicts
- Strong oxidizing agents
- Strong acids
- Strong bases
- Nitrosating agents
Safety
Safety Profile
Restricted by IFRA and SCCS as a known fragrance allergen. EU labeling is mandated above 0.001% (leave-on) and 0.01% (rinse-off). Formulations require antioxidants (e.g., 0.1% BHT or Tocopherol) to prevent sensitizing hydroperoxide formation, with peroxide value kept below 20 mmol/L.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While offering fragrance and antimicrobial benefits, allo-ocimenol presents a high sensitization risk if not meticulously formulated with antioxidants and strict peroxide control, limiting its suitability for precision skincare.
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References
Sources
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