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Moumoujus

ALLIUM SATIVUM STEM EXTRACT.

Valuable CAS 8008-99-9 / ANTIOXIDANT, HUMECTANT, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

Allium Sativum Stem Extract is a potent botanical known for its multifaceted benefits, including significant antioxidant, antimicrobial, and skin-conditioning properties. It actively supports skin health by protecting against environmental stressors and targeting microbial imbalances.

Summary

Antioxidant Humectant Skin Conditioning Emollient

Science

Mechanism of Action

This extract offers antioxidant effects by scavenging free radicals and boosting total thiols, alongside antimicrobial action via organosulfur compounds like allicin. It also interferes with skin cancer progression by downregulating VEGF and MMPs, crucial for angiogenesis and matrix degradation.

Research

Clinical Evidence

Medium confidence
Effective range 0.05–12%
Optimal

N/A

Key findings

  1. 01 Inhibited B16-F0 melanoma cell growth by 30.2% and migration by 38.5% (in vitro).
  2. 02 Demonstrated significant antibacterial activity against Streptococcus mutans and Porphyromonas gingivalis (in vitro).
  3. 03 Showed antifungal MIC against M. guilliermondii, relevant to onychomycosis (in vitro).

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH 1.2 – 6.8
0 7 14

Stability

The extract is highly unstable, with active components like allicin rapidly decomposing. Stability is significantly enhanced in acidic conditions (optimal pH 1.2 for nitrite scavenging) and under refrigerated, dark storage.

Conflicts

  • High temperatures
  • Strong oxidizing agents
  • UV light

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

While related garlic bulb ingredients have CIR review, this stem extract is nascent in cosmetic databases. It's generally non-toxic at low doses, yet garlic-derived compounds can be sensitizers.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Allium Sativum Stem Extract offers valuable antioxidant and antimicrobial benefits, but its inherent instability and potential for sensitization require precise formulation.

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