Science
Mechanism of Action
This extract's efficacy is primarily attributed to organosulfur compounds, such as allicin, which inhibit NF-κB activation and suppress pro-inflammatory cytokines like IL-6 and TNF-α. It also stimulates wound healing by upregulating Vascular Endothelial Growth Factor (VEGF) and exhibits antimicrobial activity through pathogen cell membrane disruption.
Research
Clinical Evidence
Medium confidence10%
Key findings
- 01 Topical 10% garlic extract cream significantly increased VEGF expression, accelerating wound healing in mouse models.
- 02 Aqueous extracts at 0.4% demonstrated antibacterial activity, though allicin stability is a key challenge.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
This extract is highly temperature-sensitive, degrading rapidly above 40°C. Allicin, its primary active, is most stable between pH 5.0-6.0 and quickly degrades in highly acidic (<1.5) or alkaline (>11) environments.
Conflicts
- High temperatures (>40°C)
- Strong oxidizing agents
- Highly alkaline environments (pH >11)
- Highly acidic environments (pH <1.5)
Safety
Safety Profile
While not formally reviewed by CIR, raw garlic can be a skin irritant. However, cosmetic extracts are typically highly diluted, resulting in low irritancy and comedogenicity for topical application.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A valuable multi-functional ingredient for targeted skin repair and protection, provided its inherent stability challenges are expertly managed during formulation to ensure active delivery.
Related
Similar Ingredients
Finding similar ingredients…