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Moumoujus

ALLETHRINS.

Avoid CAS 584-79-2 (D-form) / 3972-20-1 (dl-alpha) / 28434-00-6 / 34624-48-1 / FRAGRANCE, SKIN CONDITIONING

Allethrins are Type I synthetic pyrethroids primarily utilized as potent insecticides and ectoparasiticides. They are effective against various insects, including mosquitoes, and for controlling parasites like lice.

Summary

insecticide ectoparasiticide

Science

Mechanism of Action

Allethrins function as axonic poisons, binding to voltage-gated sodium channels in nerve membranes to prolong sodium influx. This leads to repetitive nerve firing, causing insect hyperactivity and eventual paralysis; in vitro human studies suggest potential for oxidative stress.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

1%

Key findings

  1. 01 At 1.0% concentration, allethrins are 100% effective as an ectoparasiticide for treating pediculosis (lice) when used correctly.
  2. 02 Undiluted technical grade allethrin applied to rabbit skin showed no significant irritation or systemic toxicity, classified as Toxicity Category IV (very slight) for skin by the EPA.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH 4 – 7
0 7 14

Stability

Highly unstable in alkaline conditions (pH > 7.0) due to rapid hydrolysis. They are sensitive to UV light and air, requiring opaque packaging or UV stabilizers for stability in slightly acidic to neutral environments.

Conflicts

  • Alkaline ingredients
  • Strong oxidizing agents
  • UV light

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
1%
Pregnancy
Caution
Sensitization risk Low

Allethrins are not standard cosmetic ingredients and lack CIR review for skincare. Regulated by EPA/FDA as pesticides, California's Safe Cosmetics Program lists them as 'Reportable' due to potential developmental and endocrine toxicity, despite minimal skin irritancy (EPA Category IV).

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Allethrins are pesticides with no established skincare benefits, potential developmental and endocrine toxicity concerns, and are not reviewed for cosmetic use, making them unsuitable for precision skincare formulations.

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