Science
Mechanism of Action
The efficacy of Alibertia Patinoi Fruit Extract stems from its phenolic compounds, including oleuropein, chlorogenic acid, and rutin. These constituents enable the extract to neutralize free radicals, offering robust antioxidant protection. Additionally, its antimicrobial properties support a balanced skin microbiome, while its comprehensive phytochemical profile aids in maintaining optimal skin condition, aligning with its traditional uses in wound healing.
Research
Clinical Evidence
Low confidenceN/A
Key findings
- 01 In vitro studies indicated bacteriostatic activity against Pseudomonas aeruginosa strains at concentrations of 187.5 mg/mL.
- 02 Bactericidal activity against Pseudomonas aeruginosa strains was observed in vitro at concentrations of 375 mg/mL.
- 03 In vitro analysis revealed an anti-proliferative effect on the Caco-2 cell line and toxicity to human conjunctive Wong-Kilbourne derivative (WKD) cell lines across a concentration range of 0.05 to 187.5 μg/mL.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The extract's natural acidity, characterized by a pH range of 3.0 to 3.5, along with its antimicrobial compounds, contributes to its stability, allowing for effective storage at room temperature or under refrigeration for up to six months.
Conflicts
- Due to its inherently low pH (around 3), heating to 121 °C may induce hydrolysis of certain polysaccharides, such as agar, gellan gum, and carrageenan.
Safety
Safety Profile
Formal safety assessments for cosmetic use by major regulatory bodies (CIR, SCCS, FDA) are currently unavailable. In vitro studies have demonstrated cytotoxicity on human conjunctive (WKD) cells at concentrations ranging from 0.05 to 187.5 μg/mL, indicating a potential for adverse cellular effects.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Despite promising in vitro antimicrobial and antioxidant activity, the absence of formal safety assessments and documented in vitro cytotoxicity on human cells raises significant concerns, making its suitability for cosmetic applications questionable without comprehensive in vivo data.
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