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Moumoujus

AKEBIA QUINATA EXTRACT.

Valuable CAS - / SKIN CONDITIONING

Akebia Quinata Extract (AQFE) is a potent antioxidant and skin-conditioning agent, clinically shown to reduce deep furrows and improve skin texture, particularly in crow's feet areas. It also functions as a moisturizer, enhancing skin hydration and overall health.

Summary

antioxidant moisturizer/humectant skin-conditioning

Science

Mechanism of Action

AQFE primarily acts via antiglycation and antioxidant pathways, preventing Advanced Glycation End Products (AGEs) formation. It reduces Carboxymethyl-lysine (CML) expression and stimulates Fibrillin-1, supporting the elastic fiber network and mitigating glycation-induced skin yellowing or stiffness.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 An 8-week application of AQFE cream significantly decreased deep furrow depth in crow's feet wrinkles and improved skin texture.
  2. 02 In vitro, AQFE exhibited dose-dependent antioxidant and antiglycation activity (25-500 μg/mL), protecting human dermal fibroblasts from oxidative stress and inhibiting cellular senescence.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 3 – 7.4
0 7 14

Stability

Aqueous and alcoholic extracts demonstrate stable antioxidant properties. For optimal stability of phenolic components in formulations, a pH range of 5.0–7.0 is typically maintained.

Conflicts

  • Strong oxidizing agents
  • High heat during processing

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Clinically validated with no primary skin irritation in human patch tests. While traditionally used safely, formal cosmetic safety assessments (CIR/SCCS) are not yet available.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Akebia Quinata Extract is a valuable anti-aging and skin-conditioning ingredient, demonstrating clinical efficacy against wrinkles and glycation with a low risk of irritation.

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