Science
Mechanism of Action
This extract operates via antioxidant and anti-inflammatory pathways, utilizing quassinoids and phenolic compounds to scavenge ROS and inhibit inflammatory cytokines like TNF-α and IL-6 by blocking NF-κB and COX-2. It also shows antimicrobial activity against Gram-positive bacteria.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Demonstrated concentration-dependent antioxidant activity, achieving 50% DPPH scavenging between 15.625 and 31.25 µg/mL.
- 02 Showed high cell viability (104%) in human gingival fibroblasts at 10 µg/mL, indicating biocompatibility.
- 03 Hydroxyl radical scavenging reached 42.34% at 1,000 µg/mL.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Ethanolic and hydroalcoholic extracts enhance antioxidant compound stability, while seed oil extracts exhibit low oxidative stability (approx. 4-5 hours).
Conflicts
- Strong oxidizing agents
- Highly alkaline environments (may degrade phenolic content)
Safety
Safety Profile
While not formally reviewed by CIR for cosmetic use, the plant is associated with potential allergenicity, notably through pollen and leaf contact in atopic individuals. However, in vitro irritancy for the extract itself is noted as low.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This ingredient offers valuable antioxidant, anti-inflammatory, and skin-protecting benefits based on in vitro data, but its use requires careful consideration due to the plant's general allergenicity potential.
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References
Sources