Science
Mechanism of Action
This extract primarily acts by inhibiting NF-κB and COX-2 pathways, thereby reducing pro-inflammatory cytokines like IL-6 and IL-8. It contains quassinoids such as ailanthone, which exhibit potent antimicrobial activity against S. aureus and C. acnes, additionally stimulating the skin's innate immune response.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 Topical application in a complex formula significantly reduced lesion size and erythema within 36 hours in subjects with mild to moderate atopic dermatitis and acne-prone skin.
- 02 Demonstrated significant inhibitory effects on sebum secretion and pro-inflammatory cytokine production in in-vitro models.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Stable in aqueous and hydro-alcoholic solutions within a broad pH range. Extreme alkalinity (above pH 9) may degrade its active quassinoid components.
Conflicts
- Strong oxidizing agents
- Highly acidic environments (< pH 3.0) may cause precipitation of certain phenolic fractions
Safety
Safety Profile
While not formally reviewed by the CIR, it is listed in the IECIC and approved for use in EU cosmetic products. Commercial blends typically recommend usage between 0.2% and 5%; however, raw, concentrated forms may pose a risk of contact dermatitis.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Ailanthus Altissima Bark Extract is a valuable ingredient, demonstrating potent anti-inflammatory, antimicrobial, and sebum-regulating effects, enhancing skin barrier function for diverse skin types.
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