Science
Mechanism of Action
This extract acts as a multi-functional agent by inhibiting tyrosinase to suppress melanin, reducing inflammation via NO, TNF-α, and iNOS inhibition, and restoring the skin barrier through TRPV3 activation. It also provides antimicrobial activity against P. acnes and S. aureus.
Research
Clinical Evidence
Medium confidence0.1%
Key findings
- 01 Clinical studies indicate antimicrobial activity against P. acnes at 0.05 mg/mL, comparable to triclosan. Potent antioxidant effects were observed with an IC50 of 8.64 μg/mL (DPPH). A 0.1% concentration showed 12-month stability of key bioactives in topical creams.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Bioactive flavonoid glucuronides are stable for 12 months in cream formulations. Avoid strong oxidizing/reducing agents, and extreme pH outside 4.0-7.0, which may degrade phenolic components.
Conflicts
- strong oxidizing agents
- strong reducing agents
- strong acids
- strong alkalis
Safety
Safety Profile
While not formally reviewed by CIR or SCCS, it has a long history of traditional use. Safety data for cosmetic use is limited but considered low risk due to presence in commercial products.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Agrimonia Pilosa Extract is a valuable, multi-functional botanical offering significant benefits for acne, inflammation, pigmentation, and barrier health across all skin types.
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References
Sources