Science
Mechanism of Action
Rich in tannins like agrimoniin and flavonoids, it functions as an astringent by contracting tissues and cross-linking proteins. It promotes healing by stimulating fibroblast conversion and increasing ECM, while also suppressing pro-inflammatory cytokines for a calming effect.
Research
Clinical Evidence
Medium confidence1%
Key findings
- 01 A 1.0% concentration significantly improved incision and excision wound healing in animal and in vitro models by enhancing myofibroblast conversion and ECM deposition.
- 02 Concentrations of 10.0-20.0% demonstrated significant antimicrobial activity against S. aureus and P. aeruginosa, alongside therapeutic potential for eczema through cytokine modulation.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Its high tannin content makes it susceptible to oxidation and color darkening. Optimal stability and phenolic integrity are maintained in slightly acidic conditions, often with ethanol or aqueous extraction.
Conflicts
- Proteins
- Alkaloids
- Heavy metal salts
- Strong oxidizers
Safety
Safety Profile
While generally safe for topical skincare, the EU SCCS previously noted potential genotoxicity for its use as an oxidative hair dye component, leading to its prohibition in that specific category. Cases of photodermatitis have been reported.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This multifaceted root extract offers scientifically-backed wound healing, anti-inflammatory, and astringent benefits, making it a valuable addition for various skin concerns, especially compromised or reactive skin.
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References
Sources