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AETOXYLON SYMPETALUM WOOD OIL.

Valuable CAS 1333524-00-7 / FRAGRANCE

This rare wood oil, also known as Crocodile Agarwood, offers significant anti-inflammatory and broad-spectrum antimicrobial benefits for the skin. It is recognized for its ability to soothe redness and support skin health.

fragrance soothing anti-inflammatory antimicrobial

Science

Its primary activity stems from over 20% sesquiterpenoids like beta-eudesmol, which inhibit pro-inflammatory cytokines to reduce redness and inflammation. It also provides broad-spectrum antimicrobial action by disrupting pathogen cell membranes.


Research

Medium confidence
Effective range 0.01–0.33%
Optimal

0.33%

Key findings

  1. 01 An in vitro MTS assay on human keratinocyte cells showed maintained cell viability at 100 µg/mL, indicating low acute cytotoxicity.
  2. 02 Demonstrated significant growth inhibition against microbial rot and fungal pathogens at 1.0% in edible film studies.

Transparency

Not commonly dusted

The Formula

Solubility
Oil
Optimal pH 4.5 – 5.5
0 7 14

Stability

This highly viscous amber oil exhibits excellent stability and low volatility, acting as a potent base note fixative for over 400 hours. It maintains stability optimally in slightly acidic skin-identical formulations (pH 4.5-5.5).

Conflicts

  • Strong oxidizing agents
  • Highly alkaline environments (may degrade ester/terpene components)
  • Synthetic polymers in high concentrations (may have low compatibility without emulsifiers)

Safety

CIR Status
Not reviewed
Max tested
0.33%
Sensitization risk Moderate

IFRA 51 restricts its use to 0.33% in leave-on skin products due to potential terpene-related sensitization. This rare oil lacks specific safety monographs from FDA or SCCS.


Your Skin

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Valuable

A valuable ingredient for targeted precision skincare, offering potent anti-inflammatory and antimicrobial benefits for compromised skin.


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