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Moumoujus

ACRYLOYL MORPHOLINE.

Avoid CAS 5117-12-4 / PLASTICISER

Acryloyl morpholine is a synthetic monomer primarily utilized as a reactive diluent in UV-curable resins for industrial applications. It is recognized as a potent skin sensitizer, presenting a significant risk for allergic contact dermatitis even at minimal exposure concentrations.

Summary

Plasticiser Reactive Diluent

Science

Mechanism of Action

As an alpha,beta-unsaturated amide, acryloyl morpholine is predicted to covalently interact with proteins within the skin via a Michael addition reaction. This mechanism is thought to be central to its strong skin sensitizing potential.

Research

Clinical Evidence

High confidence
Effective range 0.05–80%
Optimal

0%

Key findings

  1. 01 Human patch tests have consistently elicited positive reactions, indicating allergic contact dermatitis, at concentrations as low as 0.05% to 0.5%.
  2. 02 Skin sensitization and allergic contact dermatitis have been observed in users of adhesive products containing 20-80% acryloyl morpholine, and in nail product users exposed to residual monomer up to 25%.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Acryloyl morpholine is light-sensitive and should be stored refrigerated (2-8°C) in a tightly closed container, in a dry, well-ventilated area, protected from direct sunlight. It maintains stability under these recommended conditions. In UV-curable applications, the substance is expected to be integrated into the polymer matrix upon curing, rendering it non-bioavailable; however, exposure to the residual monomer can occur prior to complete polymerization.

Conflicts

  • Strong oxidizing agents

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
0%
Sensitization risk High

Acryloyl morpholine is classified as a hazardous substance, causing serious eye damage (Category 1) and acting as a skin sensitizer (Category 1). It is also harmful if swallowed (Acute Toxicity Category 4) and may induce organ damage from prolonged or repeated exposure, with irreversible corneal effects documented. It is listed on the Hazardous Chemicals Information System (HCIS) and is a priority risk reduction substance by the Swedish Chemicals Agency due to its skin sensitization properties. While submitted for testing to the National Cancer Institute, there is no FDA approval for its direct introduction into humans or animals.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Acryloyl morpholine is a highly hazardous skin sensitizer and irritant, demonstrating adverse reactions at extremely low concentrations and is explicitly deemed unsafe for direct skin contact in cosmetic formulations.

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