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ACRYLAMIDOPROPYLTRIMONIUM CHLORIDE.

Valuable CAS 45021-77-0 / NOT REPORTED

A cationic polymer designed to condition both skin and hair, enhancing softness and significantly improving surface texture. It forms a lightweight, breathable film that reduces friction and supports moisture retention.

antistatic film forming hair conditioning skin conditioning

Science

This quaternary ammonium compound carries a strong positive charge, enabling it to electrostatically bind to negatively charged skin and hair. On the skin, it forms a uniform film that smoothes texture and acts as a conditioning barrier to retain moisture.


Research

High confidence
Effective range 0.01–0.15%
Optimal

0.1%

Key findings

  1. 01 At 0.1%, it significantly enhances hair softness and improves wet combing/detangling.
  2. 02 In facial cleansers at 0.01-0.1%, it softens skin after washing, mitigating surfactant-induced dryness.
  3. 03 Evaluated at 0.15%, it improves the bioavailability of other actives and refines the texture of moisturizing formulas.

Transparency

Not commonly dusted

The Formula

Solubility
Water
Optimal pH 2 – 9
0 7 14

Stability

Highly stable across a broad pH range of 2-9, though extreme pH may reduce viscosity. It is heat tolerant up to 80°C and is typically incorporated into the water phase.

Conflicts

  • Highly anionic surfactants (may form complexes or precipitate)
  • Strongly anionic thickeners like Carbomer (can cause clumping)
  • Soap-based systems (at very high concentrations)

Safety

CIR Status
Safe as used
Max tested
1%
Sensitization risk Low

The CIR Expert Panel (2022) concluded it is safe in current practices when formulated to be non-irritating. European regulations (Annex III) also permit its use, subject to purity criteria for residual acrylamide monomers.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

Acrylamidopropyltrimonium Chloride is a valuable conditioning agent that effectively softens skin, improves texture, and counteracts dryness across a wide range of cosmetic applications.


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