Science
Mechanism of Action
The primary active, Spilanthol, acts as an N-alkylamide that rapidly inhibits micro-contractions of facial muscles for a 'Botox-like' effect. It also stimulates collagen production and organization, enhancing skin firmness and elasticity.
Research
Clinical Evidence
High confidence2%
Key findings
- 01 In vivo studies showed significant reduction in crow's feet wrinkle parameters after 28 days, with anti-wrinkle effects appearing as early as the next day.
- 02 In vitro, complete inhibition of muscle contractions was observed within 1-5 minutes, with effects lasting up to 24 hours at 1.2%.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The extract exhibits good thermal stability up to 40°C and is stable in emulsions at physiological pH (approximately 5.7). Its versatile supply in hydro-glycolic or hydro-glycerinated bases makes it suitable for various formulations.
Conflicts
- Strong oxidizing agents
- Highly acidic or highly alkaline environments
Safety
Safety Profile
While not formally reviewed by CIR, specific safety studies confirm good skin tolerability, no ocular irritation, and no systemic absorption of spilanthol. It is typically recommended at 1-2% in leave-on products.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A valuable active for rapidly smoothing expression lines and improving skin firmness through muscle relaxation and collagen network support.
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References
Sources