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ACHILLEA MILLEFOLIUM FLOWER/LEAF/STEM EXTRACT.

Valuable CAS 84082-83-7 / SKIN CONDITIONING

A multi-functional botanical extract, it visibly improves skin texture, reduces wrinkles and pores, and offers antioxidant and soothing benefits. It also provides synergistic photoprotective effects.

Soothing Antioxidant Skin Conditioning Astringent Anti-aging Photoprotective

Science

It enhances epidermal differentiation and thickness by upregulating key markers like filaggrin. Its rich flavonoid and phenolic acid content provides antioxidant defense, while it also acts as an astringent and modulates neuropeptide receptors for anti-inflammatory effects.


Research

High confidence
Effective range 0.1–2%
Optimal

2%

Key findings

  1. 01 A 2% concentration significantly improved wrinkle and pore appearance over two months, outperforming glycolic acid in skin rejuvenation.
  2. 02 At 0.5% in nanoemulsions, it boosted in vitro SPF from 14 to 22, indicating synergistic photoprotective effects with chemical filters.
  3. 03 Formulations with 0.1-0.5% extract proved non-irritating and non-sensitizing in clinical maximization tests.

Transparency

Commonly dusted
Min. effective
0.1%
Red flag below
0.04%

While proven effective at 0.5-2% for specific benefits, many commercial leave-on products utilize significantly lower concentrations (0.000005% to 0.04%), potentially offering minimal functional impact compared to reported clinical efficacy.


The Formula

Solubility
Water
Optimal pH 4 – 6
0 7 14

Stability

Highly stable in nanoemulsions; bioavailability and stability are improved when incorporated into glycol-based vehicles.

Synergies

  • Nanoemulsions (improves stability and bioavailability)
  • Glycol-based vehicles (e.g., propylene glycol, butylene glycol)
  • Chemical UV filters (for enhanced photoprotection)

Conflicts

  • Strongly acidic environments (may degrade phenolic content)
  • Strong oxidizing agents

Safety

CIR Status
Safe as used
Max tested
10%
Sensitization risk Low

The CIR Expert Panel concluded it is safe when formulated to be non-sensitizing. Formulations with 0.1-0.5% extract showed no irritation or sensitization.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

This well-researched botanical offers proven anti-aging, photoprotective, and soothing benefits, making it a valuable active for diverse skincare formulations.


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