Science
Mechanism of Action
This extract acts as an agonist for melanocortin receptor-2 and mu-opioid receptor 1, upregulating epidermal differentiation markers like filaggrin. It also exhibits anti-inflammatory effects and inhibits matrix metalloproteinases (elastase/collagenase) to preserve structural proteins.
Research
Clinical Evidence
High confidence2%
Key findings
- 01 A 2% concentration significantly improved the appearance of wrinkles and pores, increasing epidermal thickness by 10% over 2 months in a human study.
- 02 In vitro, a 5% concentration showed 19.2% inhibition of elastase and 43.8% inhibition of collagenase, indicating anti-aging potential.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Bioavailability is enhanced in glycol-based systems, with extracts typically stable in slightly acidic conditions. Aqueous extracts are common for soothing, while ethanol/oil extractions capture nonpolar compounds.
Conflicts
- Strong oxidizers
- Highly alkaline environments (can cause degradation of phenolic components)
Safety
Safety Profile
Confirmed lack of irritation or sensitization in HRIPT at 0.04%. However, caution is advised regarding potential allergens like linalool and thujone, especially when combined with other Asteraceae botanicals.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Achillea Millefolium Flower Extract is a valuable botanical active, offering significant anti-aging benefits, pore refinement, and soothing properties with a low risk of irritation across all skin types.
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References
Sources
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