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Moumoujus

ACETYLNEURAMINIC ACID.

Valuable CAS 131-48-6 / SKIN CONDITIONING, SKIN PROTECTING

Acetylneuraminic Acid (Neu5Ac) is a multi-functional ingredient known for its potent moisturizing, brightening, and skin-protecting properties. It effectively addresses hyperpigmentation and supports overall skin health across all skin types.

Summary

skin-conditioning skin-protecting humectant brightening

Science

Mechanism of Action

This ingredient functions as a powerful humectant, drawing moisture into the stratum corneum. It actively brightens skin by inducing autophagy-mediated degradation of tyrosinase, the primary enzyme in melanin synthesis, and inhibits MMP-1 to prevent collagen breakdown.

Research

Clinical Evidence

Medium confidence
Effective range 0.05–0.2%
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 3 – 10
0 7 14

Stability

Highly stable within pH 3.0 to 10.0. A 2% solution is strongly acidic (pH 1.8-2.3), necessitating buffering for formulation. Stability is significantly compromised by Hydrogen Peroxide.

Conflicts

  • Hydrogen Peroxide
  • Strongly acidic conditions (pH < 2.0)
  • Strongly alkaline conditions (pH > 11.0)

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

While not formally reviewed by CIR for cosmetics, it holds FDA GRAS (GRN 602) status for food and is EFSA certified as a 'Novel Food'. Clinical data indicates it is non-cytotoxic and well-tolerated topically at tested experimental levels.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Acetylneuraminic Acid is a valuable multi-functional ingredient, offering significant benefits for brightening, hydration, and overall skin protection with excellent compatibility across all skin types.

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