Science
Mechanism of Action
It primarily boosts Aquaporin-3 (AQP3) expression, vital for water and glycerol transport in the skin. Additionally, it counteracts inflammation by inhibiting cytokines (IL-6, TNF-alpha) and reduces oxidative stress through HO-1 induction.
Research
Clinical Evidence
High confidence1%
Key findings
- 01 Concentrations of 0.25-0.5% dose-dependently increased Aquaporin-3 (AQP3) gene expression in epidermal cells by 322- to 456-fold, significantly improving skin hydration and barrier function.
- 02 A 1.0% concentration of related IPC molecules showed significant improvements in wrinkle reduction, hydration, and skin texture over 12 weeks compared to vehicle.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Highly stable at skin-neutral pH, with optimal stability typically achieved at pH 6.5. It is miscible in water (>10%) but insoluble in alcohols and oils.
Conflicts
- low pH environments (<5.0)
- highly lipophilic anhydrous systems without proper emulsification
Safety
Safety Profile
Manufacturers classify it as safe for topical cosmetic use. Human Repeat Insult Patch Tests on related IPC compounds at 1% showed no signs of sensitization or irritation.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Acetylglutaminoyl Farnesylcysteine is an essential active for significantly enhancing skin hydration, barrier function, and overall rejuvenation through multiple mechanisms.
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References
Sources