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Moumoujus

ACETYLATED LANOLIN.

Valuable CAS 61788-48-5 / HAIR CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SKIN CONDITIONING - OCCLUSIVE

Acetylated Lanolin is a modified lanolin derivative, serving as an effective emollient and occlusive agent. It enhances skin hydration and smoothness, with reduced stickiness and odor compared to traditional lanolin.

Summary

emollient

Science

Mechanism of Action

It forms a hydrophobic, oily film on the stratum corneum, significantly reducing transepidermal water loss (TEWL). This process lubricates the skin surface, improving texture and softness.

Research

Clinical Evidence

Medium confidence
Effective range ≤37%
Optimal

2.5%

Key findings

  1. 01 Concentrations of 30% or higher elicited allergic reactions in individuals with known lanolin sensitivity, though it remains a weak sensitizer for the general population.
  2. 02 Pure (100%) acetylated lanolin alcohol is highly comedogenic (rating 4-5), but its comedogenicity significantly decreases when diluted (e.g., 2.5% in propylene glycol reduces rating to 1).

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH 4 – 9
0 7 14

Stability

Highly stable against oxidation and hydrolysis within typical cosmetic pH ranges due to the acetylation of hydroxyl groups.

Conflicts

  • Strong oxidizing agents
  • Highly alkaline environments (may cause slow deacetylation)

Safety

Safety Profile

CIR Status
Safe as used
Max tested
37%
Sensitization risk Low

The CIR Expert Panel deems it safe for topical application. While generally a weak sensitizer, concentrations of 30% or higher can trigger allergic reactions in individuals with known lanolin sensitivity.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
No Sensitive
Irritancy Low
Comedogenicity High

Our Assessment

Verdict

Valuable

A valuable occlusive emollient for dry skin formulations, effective when used in concentrations that minimize its inherent high comedogenicity and potential for sensitivity in predisposed individuals.

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