Science
Mechanism of Action
This acetylated ester enhances the skin barrier by stimulating ceramide synthesis, specifically upregulating SPTLC1 mRNA. It also provides key amino acid support for collagen stability and exhibits anti-glycation properties to prevent dermal stiffening.
Research
Clinical Evidence
Medium confidence1%
Key findings
- 01 A 1% concentration of an N-acetyl-L-hydroxyproline analog significantly reduced transepidermal water loss and alleviated pruritus over 4 weeks by upregulating ceramide synthesis genes.
- 02 In-use safety studies showed products with acetyl hydroxyproline derivatives up to 2% had no adverse effects or sensitization.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
As an ester, it is prone to hydrolysis at extreme pH values; stability is optimal in anhydrous systems or emulsions within physiological pH.
Conflicts
- Strong oxidizing agents
- Strong acids/bases
Safety
Safety Profile
Reviewed as an Amino Acid Alkyl Amide, it is clinically non-sensitizing and non-irritating at typical cosmetic use levels.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This ingredient offers valuable multi-faceted support for skin barrier health, collagen stability, and anti-aging due to its emollient and ceramide-stimulating properties.
Related
Similar Ingredients
Finding similar ingredients…