Science
Mechanism of Action
It functions as a sacrificial antioxidant, safeguarding proteins from oxidative degradation, and acts as an antagonist for the Neurokinin-1 receptor, thereby reducing neurogenic inflammation. It also serves as a precursor for serotonin and melatonin.
Research
Clinical Evidence
High confidence0.5%
Key findings
- 01 0.1-5 mM concentration protects proteins (like albumin) from oxidative and thermal degradation, acting as a sacrificial antioxidant.
- 02 0.5% concentration, as part of complexes, mitigates pro-inflammatory cytokines and reduces neurogenic inflammation via NK1 receptor antagonism.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Highly stable in powder and dilute solutions, with optimal stability between pH 4.5 and 7.0. It can remain stable up to pH 9.0 in specific buffered conditions.
Conflicts
- Strong oxidizing agents
Safety
Safety Profile
Generally recognized as safe (GRAS) by the FDA as a tryptophan derivative. Cosmetic safety assessments for similar acetylated amino acids support its safe use up to 5%.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A valuable multifunctional ingredient for soothing sensitive skin, providing potent antioxidant protection, and supporting barrier repair across all skin types.
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References
Sources