Science
Mechanism of Action
This peptide activates AdipoR1/2 receptors, enhancing skin barrier formation through filaggrin and involucrin expression. It also stimulates fibroblast proliferation and collagen production (Types I/III), while clearing senescent cells to rejuvenate the dermal matrix.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 Clinical evaluation of a serum containing this peptide demonstrated a 54% increase in skin moisturization immediately, sustaining a 35% increase after 24 weeks. It also notably improved skin elasticity and reduced fine lines and sagging.
- 02 Acting as an adiponectin agonist, the peptide induces the elimination of senescent cells (senolysis) and promotes skin barrier formation and keratinocyte production in various models.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The ingredient is water soluble and stable up to 59°C. Optimal pH is between 5.0 and 7.5; extreme pH (<4.0 or >8.0) or strong oxidizing agents should be avoided to prevent hydrolysis.
Conflicts
- strong oxidizing agents
- extreme pH environments (< 4.0 or > 8.0)
Safety
Safety Profile
While not formally reviewed by CIR, the ingredient is considered non-toxic and low-risk based on manufacturer safety profiles and its use in high-end dermatological products at concentrations up to 5%.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Acetyl Tripeptide-54 Amide is a valuable multi-functional peptide, effectively enhancing skin hydration, elasticity, and barrier function while promoting cellular rejuvenation.
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References
Sources