Science
Mechanism of Action
Acting as a Wnt signaling antagonist, this peptide downregulates MITF to inhibit tyrosinase activity and melanin synthesis. It further exhibits anti-inflammatory effects by mimicking SFRP5, counteracting pro-inflammatory Wnt5a signaling.
Research
Clinical Evidence
High confidence0.001%
Key findings
- 01 In vitro studies show significant suppression of melanogenesis by inhibiting Wnt activity, reducing melanin content, and demonstrating anti-inflammatory effects.
- 02 A topical cream with Winhibin clinically alleviated Hand-Foot Syndrome and skin reactions over 9 weeks, highlighting its soothing properties.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The peptide remains stable up to 59°C and is commonly supplied in a water-based solution, often stabilized with glycols.
Conflicts
- Strong oxidizing agents
- Proteolytic enzymes
- Strongly acidic environments (pH < 4.0)
Safety
Safety Profile
This ingredient is considered non-cytotoxic and safe for topical use at very low concentrations (parts per million), listed in EU CosIng for 'Skin Conditioning'.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A potent biomimetic peptide, Acetyl Tripeptide-53 Amide effectively targets hyperpigmentation and inflammation, offering significant skin brightening and soothing benefits for all skin types.
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