Science
Mechanism of Action
It acts as a potent antagonist to Corticotropin-Releasing Factor (CRF) receptors within the skin and hair follicles. By blocking these receptors, it inhibits the local stress response that can lead to hair thinning and premature entry into the telogen phase.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Human volunteer tests reported significant efficacy in stimulating hair growth and increasing hair diameter when applied topically.
- 02 Animal studies demonstrated significant hair regrowth in stress-induced alopecia by blocking CRF receptors.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Peptides are sensitive to heat and pH extremes; best stabilized in buffered aqueous solutions and stored cool to prevent hydrolysis.
Conflicts
- Strong acids
- Strong bases
- Proteolytic enzymes
- Strong oxidizing agents
Safety
Safety Profile
Though not CIR-reviewed, this synthetic peptide is considered well-tolerated based on dermatological testing in cosmetic formulations.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This potent CRF antagonist is a valuable ingredient for addressing stress-induced hair loss and improving overall scalp and skin health.
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References
Sources
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