Science
Mechanism of Action
It selectively inhibits Matrix Metalloproteinases (MMPs), preventing the degradation of collagen and elastin in the extracellular matrix. Additionally, it stimulates Collagen IV, skin barrier proteins (TGM1, Filaggrin), and Aquaporin 3 for improved hydration and structural integrity.
Research
Clinical Evidence
Medium confidence0.025%
Key findings
- 01 A cream with 5% Vanistryl complex (containing this peptide) improved wrinkle visual aspect by 38.89%, tightness by 70.83%, and softness by 133.33% in 12 volunteers with recent stretch marks over 60 days.
- 02 In vitro studies demonstrated complete (100%) inhibition of MMP-2 activity and 63.1% inhibition of MMP-9, thereby reducing Type I collagen degradation.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Highly stable within pH 4.0–8.0. Incorporate at the end of the formulation process during the cooling phase (below 40°C) to prevent thermal degradation.
Conflicts
- Strong oxidants
- Electrophiles
- Ionic surfactants
Safety
Safety Profile
While related peptides like Tripeptide-1 are considered safe, Acetyl Tripeptide-30 Citrulline specifically has not yet undergone a formal CIR safety assessment. It is used in commercial complexes at recommended levels of up to 5%.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Acetyl Tripeptide-30 Citrulline is a valuable peptide for improving skin elasticity and reducing stretch marks by protecting collagen and enhancing skin structure.
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References
Sources