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Moumoujus

ACETYL TETRAPEPTIDE-40.

Valuable / SKIN CONDITIONING

Acetyl Tetrapeptide-40 is a precision peptide developed to effectively target and reduce skin redness, erythema, and the appearance of vascular imperfections like telangiectasia. It also provides significant soothing benefits, alleviating skin sensitivity and post-inflammatory hyperpigmentation.

Summary

soothing skin conditioning anti-inflammatory anti-redness anti-aging

Science

Mechanism of Action

This peptide operates by inhibiting the inflammatory LL-37 pathway, which reduces the release of pro-inflammatory cytokines such as IL-6 and IL-8. This action diminishes skin redness and sensitivity. Additionally, it prevents Matrix Metalloproteinase (MMP-1) activation, protecting collagen and promoting skin elasticity.

Research

Clinical Evidence

High confidence
Effective range 0.05–0.05%
Optimal

0.05%

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 7
0 7 14

Stability

Stable in aqueous solutions but sensitive to high temperatures; it should be incorporated during the cooling phase (below 40°C) to prevent denaturation.

Conflicts

  • Strongly acidic environments (pH < 4.0)
  • Strongly alkaline environments (pH > 8.0)
  • Strong oxidizing agents

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
2%
Sensitization risk Low

While not individually reviewed by CIR, Acetyl Tetrapeptide-40 is widely considered safe for cosmetic use at manufacturer-recommended levels, typically as a 2% trade name solution containing around 0.05% active peptide.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Acetyl Tetrapeptide-40 is a valuable ingredient for addressing chronic redness, sensitivity, and visible capillaries, offering significant soothing and anti-aging benefits for a wide range of skin types.

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