Science
Mechanism of Action
This peptide stimulates extracellular matrix synthesis, increasing Type III collagen by up to 65% and laminins by up to 285%. It strengthens the dermal papilla and dermal-epidermal junction, while also modulating DHT levels and reducing micro-inflammation.
Research
Clinical Evidence
High confidence5%
Key findings
- 01 A 4-month placebo-controlled study showed a 5% concentration significantly increased the anagen/telogen ratio by 46% and improved hair density.
- 02 A 24-week trial with a 5% concentration demonstrated comparable efficacy to 3% minoxidil in increasing terminal hair count (8.3% vs 8.7%) without adverse reactions.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Highly stable in aqueous solutions at room temperature. Best added during the cool-down phase (below 40°C) to prevent peptide degradation.
Conflicts
- Strong oxidizing agents
- Strongly acidic environments (pH < 4.0)
- Strongly alkaline environments (pH > 8.0)
- Proteolytic enzymes
Safety
Safety Profile
Widely considered safe for cosmetic use, typically in 0.001-5% commercial blends. It is non-irritating to the skin but may cause mild eye irritation.
Your Skin
Skin Compatibility
Our Assessment
Verdict
With strong clinical backing and a multi-faceted mechanism, Acetyl Tetrapeptide-3 is a valuable asset for hair density and skin protection formulations.
Related
Similar Ingredients
Finding similar ingredients…
References
Sources