Science
Mechanism of Action
This peptide targets the dermis by activating FBLN5 and LOXL1 genes, crucial for organizing functional elastin fibers and improving cellular adhesion to the extracellular matrix. It also mimics thymopoietin to stimulate skin immune defenses and epidermal regeneration.
Research
Clinical Evidence
High confidence0.05%
Key findings
- 01 Induces Fibulin-5 and LOXL1 expression, enhancing elastin fiber organization and cellular cohesion.
- 02 Maximally recommended for significant up-regulation of collagen I and elastin synthesis, improving facial contour and reducing skin sagging.
Transparency
Dusting Analysis
Commercial 'solution' forms often contain a much lower active peptide concentration (e.g., ~0.005% active peptide in a 2% solution). Claims exceeding 0.05% active peptide or high percentages without clarifying active concentration may indicate dusting.
The Formula
Formulation
Stability
Stable in neutral aqueous solutions; should be added during the cooling phase (below 40-45°C) to avoid heat degradation and protected from prolonged light exposure.
Conflicts
- Strong oxidizing agents
- Strong acids or bases
- Proteolytic enzymes
Safety
Safety Profile
While not CIR-reviewed, similar small peptides are classified as safe. Manufacturer data indicates it is non-hazardous and non-sensitizing at recommended levels.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Acetyl Tetrapeptide-2 is a valuable ingredient for advanced skincare formulations, effectively targeting skin sagging and promoting regeneration through proven elastin and collagen synthesis, alongside immune support.
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