Science
Mechanism of Action
This opioid-mimetic peptide binds to μ-opioid receptors on cutaneous nerve endings, increasing sensory neuron excitation thresholds. This action reduces the release of pro-inflammatory neuromediators like CGRP, thereby decreasing skin hyperreactivity.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 A clinical study on 20 individuals demonstrated that 0.0015% twice-daily for four days significantly raised the discomfort threshold to capsaicin, effectively reducing skin sensitivity.
- 02 A dosage range of 0.2-6% is identified for anti-allergic, anti-inflammatory, and neuro-soothing effects, specifically for improving the skin's tolerance and decreasing nerve sensitivity.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Highly stable when N-acetylated, but susceptible to hydrolysis at extreme pH or temperatures. Optimal stability is often achieved by storing as a stock solution at -20°C or -80°C.
Conflicts
- strong oxidizing agents
- strong acids
- strong bases
- proteolytic enzymes
Safety
Safety Profile
Suppliers deem it safe and non-irritating, though it lacks official review by CIR or SCCS as a standalone ingredient. It is registered with FDA UNII 6K389LE0MV.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This potent neuro-soothing peptide is valuable for precisely reducing skin sensitivity and enhancing comfort across all skin types.
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References
Sources