Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

ACETYL SH-TRIPEPTIDE-3 AMIDE.

Valuable / SKIN CONDITIONING

This advanced growth factor mimetic peptide supports comprehensive skin rejuvenation by promoting fibroblast proliferation and enhancing extracellular matrix components, leading to improved hydration and reduced hyperpigmentation. It is particularly effective in high-end anti-aging applications, stimulating essential collagen and elastin production.

Summary

skin conditioning cell-communicating ingredient

Science

Mechanism of Action

It functions as a mimetic of Epidermal Growth Factor (EGF) and Fibroblast Growth Factor (FGF), binding to the EGFR to stimulate cell growth, proliferation, and differentiation. This action supports skin regeneration and boosts water retention by inducing hyaluronan-related gene expression.

Research

Clinical Evidence

High confidence
Effective range 0.0002–1.2%
Optimal

1.2%

Key findings

  1. 01 Clinical trials demonstrate bioactivity at 0.0002% for ECM remodeling, enhanced hydration, and anti-hyperpigmentation. Manufacturer data reports efficacy at 1.2% for stimulating keratinocyte and dermal fibroblast growth, boosting collagen and elastin production.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 7
0 7 14

Stability

This highly hydrophilic peptide remains stable during standard cosmetic manufacturing processes. It is often supplied in a Butylene Glycol base to enhance stability and penetration.

Conflicts

  • Strong oxidizing agents
  • Strongly acidic environments (pH < 4.0)
  • Strongly alkaline environments (pH > 8.0)

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
1.2%
Sensitization risk Low

While specifically 'Acetyl sh-Tripeptide-3 Amide' is not formally reviewed by the CIR, similar acetylated peptides are generally considered safe. Manufacturer data suggests safe use up to 1.2% in active complexes.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Acetyl sh-Tripeptide-3 Amide is a valuable peptide, effectively mimicking growth factors to stimulate skin regeneration, collagen production, and hydration across all skin types with low irritancy risk.

Related

Similar Ingredients

Finding similar ingredients…