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ACETYL SH-TETRAPEPTIDE-2 AMIDE.

Essential / SKIN CONDITIONING

A synthetic biomimetic peptide engineered to visibly firm and lift skin, refine facial contours, and enhance skin barrier function. It supports overall skin conditioning and provides comprehensive anti-aging benefits.

Skin conditioning Anti-aging Firming Lifting Skin barrier support Improves elasticity

Science

This peptide mimics thymopoietin, stimulating crucial proteins like FBLN5 and LOXL1, essential for robust elastic fiber assembly and skin architecture. It also epigenetically rejuvenates skin’s biological age and supports skin immunity by enhancing Langerhans cell maturation.


Research

High confidence
Effective range 0.5–1%
Optimal

N/A

Key findings

  1. 01 In vivo studies demonstrated significant improvement in skin firmness and a visible 'lifting' effect on jawline and facial contours within 28-56 days.
  2. 02 Clinical evaluation showed enhanced epidermal thickness and improved skin barrier function by modulating epigenetics and increasing structural protein expression.

Transparency

Not commonly dusted

The Formula

Solubility
Water
Optimal pH 4 – 7
0 7 14

Stability

Highly stable in aqueous solutions at room temperature. For optimal peptide integrity, incorporate into emulsions during the cooling phase below 40°C.

Conflicts

  • Strong oxidizing agents
  • Strongly acidic environments (pH < 3.0)
  • Proteolytic enzymes

Safety

CIR Status
Not reviewed
Max tested
1%
Sensitization risk Low

Although not individually reviewed by CIR, this peptide belongs to a class of synthetic peptides generally considered safe in cosmetics. Manufacturers typically recommend a 0.5-2.0% usage level for the diluted peptide solution in final products.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Essential

This biomimetic peptide offers robust anti-aging benefits, including visible lifting, firmness, and enhanced barrier function, making it a highly effective ingredient for skin rejuvenation.


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References