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ACETYL SH-OLIGOPEPTIDE-29 SP.

Valuable / SKIN CONDITIONING, SKIN PROTECTING

A biotechnologically produced acetylated single peptide, this ingredient functions as a skin-conditioning and protecting agent. It is designed to enhance skin's structural integrity and repair.

skin conditioning skin protecting

Science

This biomimetic peptide enhances skin penetration through acetylation, mimicking growth factors. It targets TGF-β pathways to stimulate fibroblasts, increasing collagen and elastin synthesis for improved barrier function.


Research

Medium confidence
Effective range 0.001–0.005%
Optimal

N/A

Key findings

  1. 01 In vitro testing on human dermal fibroblasts (0.001% - 0.005%) demonstrated significant upregulation of TGF-β signaling, stimulating Type I Collagen and Elastin synthesis, and promoting ECM structural integrity.

Transparency

Not commonly dusted

The Formula

Solubility
Water
Optimal pH 5 – 7
0 7 14

Stability

Peptides of this class are sensitive to extreme temperatures and hydrolysis. Acetylation provides slightly better stability against enzymatic degradation; add below 40°C during the cooling phase.

Conflicts

  • Strong oxidizers
  • Strong acids (below pH 4.0)
  • Strong bases (above pH 8.0)
  • Proteolytic enzymes

Safety

CIR Status
Not reviewed
Sensitization risk Low

Not yet formally reviewed by CIR or SCCS due to novelty. Standard peptide safety profiles suggest low systemic toxicity and high skin compatibility.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

A promising biomimetic peptide shown to boost collagen and elastin production, supporting skin repair and anti-aging benefits across all skin types.


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References