Science
Mechanism of Action
By competitively inhibiting Keap1, Acetyl SH-Heptapeptide-1 activates the Nrf2 transcription factor, thereby upregulating the skin's internal antioxidant and detoxification enzymes. This action provides robust protection against cellular damage and premature aging.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 An in vivo study at 2% demonstrated a 20% reduction in UV-induced DNA damage and a 6% decrease in Langerhans cell depletion.
- 02 Cell culture assays at 0.11% inhibited sunburn cell formation by 75% and reduced Langerhans cell depletion by 39%.
- 03 Clinical trials utilizing 1-3% concentrations showed activation of detoxification enzymes and protection against oxidative stress-induced skin aging.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
This peptide is highly stable across a wide pH range (3-12) and is thermostable up to 45°C for short durations. It is often delivered via liposomal dispersion to optimize skin penetration.
Conflicts
- Strong oxidizing agents
- Extreme heat (above 45°C) during formulation
- Strong acids or bases outside the 3-12 pH range
Safety
Safety Profile
Generally regarded as safe at typical usage levels (1-3%), this synthetic peptide lacks specific FDA restrictions. While CIR has not issued a standalone review, its safety profile is considered low risk.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Acetyl SH-Heptapeptide-1 is a valuable ingredient for fortifying skin resilience, significantly enhancing natural antioxidant defenses and mitigating environmental damage.
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References
Sources