Science
Mechanism of Action
Mimicking Insulin-like Growth Factor 1 (IGF-1), this peptide stimulates dermal fibroblasts to synthesize extracellular matrix proteins including collagen, elastin, and hyaluronic acid. It also inhibits collagen degradation and supports skin barrier repair.
Research
Clinical Evidence
High confidence0.1%
Key findings
- 01 A face cream with 0.01% - 0.1% peptide showed significant improvements after 4 weeks: skin hydration (+43.1%), gross elasticity (+5.8%), and reduction in skin roughness (-13.0%).
- 02 Twice-daily serum use improved fine wrinkles (+19%), skin compactness (+14%), and brightness (+33%), with excellent tolerability reported by all participants.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Optimal stability is achieved in buffered aqueous solutions (e.g., 20 mM Phosphate buffer) and can be enhanced with excipients like L-Arginine. Recommended storage is 2-8°C for solutions or -20°C for long-term powder stability.
Conflicts
- Strongly acidic environments (pH < 5.0)
- Strong oxidizing agents
- Proteolytic enzymes
Safety
Safety Profile
Recognized by EU CosIng and PCPC, this ingredient has shown excellent tolerability and zero adverse effects in human clinical studies.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This peptide is an essential ingredient for advanced anti-aging formulations, offering comprehensive benefits for skin structure, hydration, and resilience with excellent tolerability.
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References
Sources