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ACETYL PROLINE.

Valuable CAS 68-95-1 / SKIN CONDITIONING - EMOLLIENT

Acetyl Proline is an N-acetylated amino acid functioning primarily as a skin-conditioning emollient and humectant. It enhances skin hydration and suppleness, suitable for a wide range of skin types.

emollient humectant skin-conditioning

Science

This ingredient acts as a humectant and emollient, structurally mimicking collagen-related peptides. Its derivatives can reversibly enhance transdermal permeation by interacting with stratum corneum lipids without damaging skin proteins.


Research

Medium confidence
Effective range ≤10%
Optimal

N/A

Key findings

  1. 01 Human studies found acetyl proline at concentrations up to 10% in cream to be a non-irritant and non-sensitizer.
  2. 02 An in vitro MatTek EpiDerm assay indicated mild irritation for a cream containing 8% acetyl proline.

Transparency

Not commonly dusted

The Formula

Solubility
Water
Optimal pH 4 – 8
0 7 14

Stability

Highly stable in aqueous solutions, maintaining integrity across a broad pH range of 2 to 9. Optimal formulation typically occurs near physiological pH (5.2-7.0) for skin compatibility.

Conflicts

  • Strong oxidizing agents
  • N-nitroso compounds (avoid in formulations prone to nitrosamine formation)

Safety

CIR Status
Safe as used
Max tested
10%
Sensitization risk Low

The CIR Expert Panel concluded Acetyl Proline is safe in current practices of use up to 10% when formulated to be non-irritating, consistent with human studies that found no irritation or sensitization.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Valuable

Acetyl Proline is a valuable, safe humectant and skin conditioner, broadly tolerated across skin types, with potential to enhance skin hydration and product efficacy.


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