Science
Mechanism of Action
This ingredient, and its close relative Acetyl Hexapeptide-8 Amide, functions by interfering with the release of neurotransmitters, specifically acetylcholine, responsible for stimulating facial muscle contractions. It achieves this by disrupting the formation and stabilization of the SNARE complex, a process analogous to the action of botulinum toxin type A. This leads to a temporary relaxation of targeted facial muscles, thereby minimizing the formation and depth of dynamic wrinkles and expression lines.
Research
Clinical Evidence
Low confidence10%
Key findings
- 01 Efficacy in reducing periorbital wrinkles when applied twice daily for 30 days in an oil-in-water emulsion, at a 10% concentration.
- 02 Inhibits decreases in type I collagen levels and skin thickness in an oil-and-water emulsion, at a 10% concentration (referring to Acetyl Hexapeptide-3, a related peptide).
Transparency
Dusting Analysis
Clinical studies demonstrating efficacy for related hexapeptides typically utilize concentrations around 10%. However, the Expert Panel for Cosmetic Ingredient Safety (CIR) concluded that Acetyl Hexapeptide-8 Amide is safe in cosmetics only at concentrations up to 0.005%. This significant discrepancy implies that a product formulated for efficacy might exceed safety recommendations, or a product formulated to CIR safety limits would likely fall below clinically effective concentrations, potentially constituting 'dusting'.
The Formula
Formulation
Stability
Aqueous solutions should not be stored for more than one day to maintain stability.
Safety
Safety Profile
The Expert Panel for Cosmetic Ingredient Safety (CIR) determined Acetyl Hexapeptide-8 Amide to be safe for cosmetic use at concentrations up to 0.005%. Data is insufficient to evaluate safety at higher concentrations for this related peptide. It is not currently restricted in the EU and is reported in the FDA's VCRP for use in a substantial number of cosmetic products.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While related hexapeptides demonstrate promising wrinkle-reducing effects and collagen support at higher concentrations (10%), the maximum recommended safe concentration for a closely related peptide (0.005%) is significantly lower, raising questions about its clinical efficacy within safe formulation limits for ACETYL HEXAPEPTIDE-68 AMIDE ACETATE.
Related
Similar Ingredients
Finding similar ingredients…