Science
Mechanism of Action
Functioning as a humectant, Acetyl Glutamic Acid works by drawing water molecules from the environment and the deeper layers of the skin to the outermost stratum corneum. This action helps to fortify the skin's natural moisture barrier, protecting against transepidermal water loss and mitigating concerns such as dryness, tightness, and flaking. It may also support the maintenance of a healthy skin pH.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
This ingredient exhibits a predicted pKa of 3.45±0.10. Its carboxyl groups are deprotonated at physiological pH (7.4). General glutamic acid derivatives can experience lability when formulated below pH 2 or above pH 13.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel deemed Acetyl Glutamic Acid safe for use in cosmetic applications and concentrations, provided that the final formulation is non-irritating. An in vivo dermal irritation study showed negative results. The Joint FAO/WHO Expert Committee on Food Additives (JECFA) also found no safety concerns at current intake levels when utilized as a flavoring agent.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Acetyl Glutamic Acid is a valuable humectant and skin conditioning agent, safe for use in formulations targeting dryness and barrier support, with a low irritancy potential.
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