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Moumoujus

ACETANILID.

Avoid CAS 103-84-4 / FRAGRANCE, PERFUMING

Acetanilid is an organic compound historically recognized for its analgesic and antipyretic properties, though its use was largely discontinued due to toxicity. In cosmetic applications, its primary function is as a stabilizer for hydrogen peroxide, with unsubstantiated claims of broader skin benefits.

Summary

Stabilizer Fragrance Masking Agent Bleaching Agent

Science

Mechanism of Action

While Acetanilid's systemic action involves metabolizing to paracetamol to inhibit COX enzymes, its specific mechanisms on the skin for cosmetic benefits lack detailed clinical substantiation. It primarily functions to stabilize hydrogen peroxide in formulations, thereby preserving product integrity. Claims of antimicrobial, anti-inflammatory, or antioxidant properties on the skin are not supported by clinical data.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH 5 – 7
0 7 14

Stability

Acetanilid generally maintains stability under most conditions, however, it is susceptible to degradation upon prolonged exposure to air. Hydrolysis can occur when the compound is subjected to strong acids or bases. An aqueous solution at a concentration of 10 g/L exhibits a pH range of 5 to 7 at 25°C. Intense heating may lead to the formation of explosive mixtures with air.

Conflicts

  • strong oxidizing agents
  • caustics
  • alkalies
  • strong acids
  • phenol
  • resorcinol
  • thymol

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

Acetanilid has not undergone review by the Cosmetic Ingredient Review (CIR). The FDA prohibits cosmetic products from containing ingredients that render them harmful under intended or customary use. Ingestion of Acetanilid is known to cause severe systemic side effects, including methemoglobinemia and hemolytic anemia. Topically, it has been associated with contact dermatitis and eczematous skin eruptions. It carries hazard statements, such as H302 (Harmful if swallowed). Due to its documented toxicity, Acetanilid is considered unsafe for general cosmetic applications, although it is utilized as a stabilizer for hydrogen peroxide in specific industrial and cosmetic products (e.g., hair and tooth bleaching) at particular usage rates.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Due to significant safety concerns, including potential for systemic toxicity and topical sensitization, and a lack of substantiated cosmetic benefits, Acetanilid is strongly advised against for general skincare formulations.

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