Science
Mechanism of Action
This compound operates as a humectant by increasing the water content within the skin's uppermost layers, actively drawing moisture from the surrounding environment. It also contributes to skin conditioning, leaving the skin feeling smoother and softer.
Research
Clinical Evidence
High confidence7.5%
Key findings
- 01 Human repeated insult patch tests confirmed safety for leave-on applications, demonstrating no primary irritation or sensitization.
- 02 Formulations containing this concentration were found to be non-irritating to the eyes in ocular irritation studies.
- 03 In guinea pig maximization tests, Acetamide MEA was classified as a non-sensitizer.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Acetamide MEA demonstrates stability across the typical pH ranges encountered in skin and hair care formulations; the ingredient itself has a pH of 7.1.
Conflicts
- nitrosating agents
- significant amounts of free acetamide
- strong acids
- strong oxidising agents
- strong bases
- triboluminescent materials
Safety
Safety Profile
The CIR Expert Panel concluded Acetamide MEA is safe in rinse-off products and in leave-on products at concentrations not to exceed 7.5%. It is crucial that cosmetic formulations containing Acetamide MEA do not include nitrosating agents or significant free acetamide, as this could lead to the formation of N-nitroso compounds, which are potential carcinogens. The FDA lists N-acetyl ethanolamine (Acetamide MEA) as an approved indirect food additive for incidental food contact. SCCS status was not found in the provided research.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Acetamide MEA is a valuable humectant and skin conditioning agent with a low irritation risk, safe for use in leave-on products up to 7.5% when formulated carefully to avoid specific incompatibilities.
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References
Sources