Science
Mechanism of Action
Inhibits pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) through glycyrrhizin and flavonoid compounds while stabilizing cellular membranes to reduce edema and irritation. Alkaloids and tannins provide antimicrobial protection by disrupting pathogenic bacterial cell walls, supporting skin barrier integrity.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Demonstrated 67.10% anti-inflammatory efficacy comparable to acetylsalicylic acid in croton oil-induced edema models (Georgewill et al., 2009)
- 02 Exhibited potent antimicrobial activity at 0.6 mg/ml concentration against skin-colonizing pathogens (Molgaard et al., 2001)
Transparency
Dusting Analysis
Limited commercial usage due to safety concerns and regulatory uncertainty around botanical extracts from plants containing toxic compounds
The Formula
Formulation
Stability
Higher bioactive yield achieved in ethanolic systems, though aqueous formulations remain functionally stable. Nanoemulsion technology recommended to enhance bioavailability of secondary metabolites.
Conflicts
- Strong oxidizing agents
- Highly acidic formulations (pH <4) may degrade glycyrrhizin glycosides
Safety
Safety Profile
Root extracts considered safer than seed portions which contain toxic abrin compound. Limited clinical safety data for cosmetic leave-on applications requires cautious formulation approach.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Promising anti-inflammatory efficacy but regulatory uncertainty and limited safety data restrict mainstream cosmetic applications.
Related
Similar Ingredients
Finding similar ingredients…
References
Sources
Keep exploring
From ingredients to everyday care.
Sensitive skin ↗
Start with comfort, product choices and the questions to ask.
Barrier support ↗
Understand moisture, lipids and the limits of ingredient claims.
Ingredient names help you read a label. They do not establish how a finished product will perform. Explore The Garden.