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Moumoujus

6-METHYL COUMARIN.

Avoid CAS 92-48-8 / FRAGRANCE, PERFUMING

A coumarin derivative with demonstrated melanogenesis-promoting properties that enhances skin pigmentation through activation of specific cellular pathways. Despite its biological activity, this ingredient carries significant regulatory restrictions due to photocontact sensitization concerns and is largely prohibited in cosmetic applications.

Summary

Melanogenesis enhancer Fragrance component (restricted)

Science

Mechanism of Action

Enhances melanin production by activating GSK3β/β-catenin and PKA/CREB signaling pathways while upregulating key melanogenic proteins (MITF, tyrosinase, TRP-1, TRP-2) and inhibiting ERK and AKT phosphorylation that normally suppress pigment synthesis

Research

Clinical Evidence

Low confidence
Effective range 125–250%
Optimal

0.003%

Transparency

Dusting Analysis

Not commonly dusted
Min. effective
0.003%
Red flag below
0.003%

Regulatory restrictions and safety concerns make this ingredient unsuitable for dusting; maximum permitted concentration is extremely low at 0.003%

The Formula

Formulation

Solubility
Oil
Optimal pH 6.8 – 7.4
0 7 14

Stability

Exhibits excellent thermal stability and maintains integrity across pH ranges 1.2-7.4, with optimal stability in neutral conditions

Conflicts

  • Strong oxidizing agents
  • UV exposure conditions
  • Aerosol formulation systems

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
0.003%
Sensitization risk High

FDA discontinued approval for sunscreen use in 1978 due to photocontact sensitization; IFRA prohibits fragrance applications; limited to 0.003% in Chinese cosmetic regulations

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Despite interesting melanogenesis properties, regulatory restrictions and high sensitization risk make this ingredient unsuitable for modern skincare formulations.

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